Lyophilization of Complex Drug Products: Formulation Challenges and Scale-Up

What’s In This Tech Brief

Lyophilization (also known as freeze drying) is a process in which a liquid is converted to a solid through sublimation and desorption of water or other solvents. It is often used to stabilize active pharmaceutical ingredients (APIs) and formulations that are not stable in liquid or frozen form. Because lyophilization does not require heat, it is an ideal drying method for thermally sensitive APIs and biologics, such as proteins and peptides.

In this tech brief the LLS Health team highlights:

• Lyophilization Equipment and Components
• The Lyophilization Process & Scale-up
• Formulating Products for Lyophilization