Incorporation of Dexamethasone Into Silicone Drug-Device Combination Products

Updated on June 5, 2020

What’s In This Tech Brief

Dexamethasone is a corticosteroid with anti-inflammatory and immunosuppressant properties. It has been used since the 1940s to treat a variety of conditions, including arthritis asthma, ocular inflammation, and certain autoimmune disorders. In recent years, there has been an increased interest in incorporating dexamethasone into medical devices. A device containing dexamethasone can help decrease inflammation, suppress the body’s natural immune response to foreign objects, and reduce the size of the fibrous capsule that forms after implantation. Dexamethasone’s low protein affinity and long half-live allow it to provide long-lasting nati-inflammatory effects, making the drug an attractive option for long-term implants that need continuous protection against inflammation.

In this tech brief, we focus on:

  • Products that contain dexamethasone
  • Manufacturing processes
  • Chemical stability of dexamethasone

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