Scientific Publications

Ethylene-vinylacetate Intravaginal Rings for Zero-order Release of an Antiretroviral Drug

Ethylene-vinylacetate (EVA) intravaginal rings (IVRs) containing the antiretroviral Dapivirine, were prepared by injection molding. In-vitro release was first-order kinetics, scaled linearly with drug loading and depended weakly on EVA properties. IVRs containing a newly developed microencapsulated drug prepared by a commercially-viable manufacturing processes exhibited zero-order release (90d) and good shelf-stability.

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