Published Articles

Vaccine Technologies & the Rationale for New Nanoparticle Formulations

Two important vaccine advances have been the development of nanoparticle-based vaccine formulations and the identification of unique microbial products that are agonists for immunologic receptors: virus-like particles (VLPs) or nanoparticles, and Toll-Like Receptor (TLR) agonists, respectively. 1-3 The immune system continuously screens for and interacts with microbes, identifying them as foreign and targeting them for immune responses. The immune system has evolved to use these unique physical and chemical attributes, TLRs for instance, to recognize microbes and specifically respond with protective responses.

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