Published Articles

TMC120 Blocks HIV-1 Infection In Cellular And Human Cervical Tissue Models

TMC120 is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that demonstrates potent anti HIV-1 activity, a good resistance profile and efficacy in the vaginal hu-SCID mouse model of transmission. To evaluate the potential of this compound as active ingredient in a microbicide formulation, we have investigated TMC120 as a base compound using cellular and human cervical explant models. Furthermore, we have optimized its activity through rational formulation design.

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