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The relentless effort to curtail the HIV pandemic continues as researchers aggressively investigate alternative prevention tools

A global, large-scale collaborative project involving world-renowned scientists is underway that seeks to cultivate combinations of highly active specifically targeted microbicides for vaginal and rectal application, known as CHAARM. The CHAARM project, which stands for Combined Highly Active Anti-retroviral Microbicides, aims to explore the microbicide potential of protease inhibitors and will test them in combination with inhibitors of HIV-1 reverse transcriptase, integrase or fusion inhibitors, using a number of highly developed drugs.

The purpose of this is to develop new microbicides and research new targets that would focus on inhibition of HIV-1 at rectal and vaginal mucosae.

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