Published Articles

Selection of Active Pharmaceutical Ingredients (APIs) and Excipients for Topical Formulations

Transdermal drug delivery (TDD) is a viable option for systemic delivery of select drugs. It provides advantages, such as avoidance of first-pass metabolism, patients’ improved compliance, controlled or sustained release, and decreased side effects. This article focuses on transdermal delivery via application of a topical, semisolid formulation in the form of a gel, lotion, or cream. The authors discuss physicochemical criteria for selection of APIs and excipients for this type of delivery.

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