Published Articles

Phase III Modeling AIDS 06

Given the complex nature of microbicide efficacy studies and the large financial commitment required to conduct these studies, a costing model was developed to identify major cost drivers and to project cost expenditures over time. Initially, a static model was developed that comprehensively estimated costs and timeline based on one sample size. A dynamic simulation model was then built that allows user input to vary by study size, statistical parameters, enrollment forecasts, number of sites, costs associated with salaries, laboratory procedures and facilities. The outputs are study size, overall study timeline, timeline of visits, and cash flow.

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