Published in Pharmaceutical Technology, 43 (6) 2019.
Poor solubility is becoming increasingly prevalent within bio/pharma drug development and is a trend that is anticipated to continue to grow as a result of the industry’s drive toward the development of more molecularly complex chemical entities. “Without exploring alternative formulation techniques, actives that are highly effective in theory or during in-vitro testing may never progress through the development pipeline, and patients may never be able to benefit from them,” states Robert Lee, PhD, President of the CDMO Division of LLS Health. “Therefore, exploration of effective methods to improve solubility or dissolution rates of these complex molecules is vital.”
In this article, Dr. Lee explores a range of techniques to enhance solubility or improve dissolution rate of drugs, including:
- Amorphous solid dispersions
- Complex formation
- Nanomilling – learn more about our Nanomilling Feasibility Program
- Combination approaches, including the use of LyoCells®